针对非伤寒型沙门氏菌的新兴策略:从发病到治疗
Cristina Mihaela Sima1,2, Elena Roxana Buzilă1,3, Felicia Trofin1
1Department of Preventive Medicine and Interdisciplinarity-Microbiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Current issues in molecular biology
|July 26, 2024
概括
非伤寒型沙门氏菌 (NTS) 感染导致全球数百万人的疾病和死亡. 本综述涵盖了NTS的致病性,抗微生物药物耐药性的上升,并探索了应对这一公共卫生挑战的替代疗法.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 非伤寒型沙门氏菌 (NTS) 感染对全球健康构成重大负担,每年造成数百万例疾病和数万例死亡.
- 增加的抗菌素耐药性,特别是多药耐药性 (在欧洲为22.6%),使治疗复杂化,并需要新的治疗策略.
研究的目的:
- 提供对非伤寒型沙门氏菌感染的全面审查.
- 阐明NTS病原和侵袭性疾病的分子机制.
- 检查NTS中抗菌素耐药性的全球格局和机制.
主要方法:
- 文献综述侧重于NTS感染,病原和抗菌素耐药性.
- 对NTS发病率和耐药性模式的全球数据的分析.
- 探索新兴的替代治疗方法.
主要成果:
- NTS感染与严重的发病率和死亡率有关,可能导致严重的短期和长期并发症.
- 抗菌素耐药性是一个越来越令人担忧的问题,导致频繁的治疗失败.
- 替代疗法在管理NTS感染方面表现有前途.
结论:
- 了解NTS病原和耐药机制对于有效控制至关重要.
- 由于抗生素耐药性增加,需要紧急开发新的治疗方案.
- 探索替代治疗方法对于应对NTS感染带来的挑战至关重要.
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