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卵巢癌中复杂的瘤微环境:治疗挑战和机会

Bianca Garlisi¹, Sylvia Lauks¹, Caroline Aitken¹

¹Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

Current oncology (Toronto, Ont.)

|July 26, 2024

概括

卵巢癌瘤微环境 (TME) 是复杂的,包括功能失调的血管和免疫抑制细胞. 这些因素阻碍了药物输送和免疫治疗的有效性,需要新的治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

卵巢癌 (OC) 中的瘤微环境 (TME) 是高度复杂的.
在OC中,功能失调的血管系统导致输液不良,缺氧和间歇性液体压力 (IFP) 增加.
这些条件阻碍了治疗剂的输送到瘤中.

研究的目的:

审查OC TME的组成部分.
讨论TME特征如何抑制治疗疗效.
探索克服TME媒介抑制的策略.

主要方法:

关于卵巢癌瘤微环境研究的文献综述.
对血管功能障碍和免疫抑制细胞的作用的分析.
检查针对TME的治疗策略.

主要成果:

OC TME表现出快速,功能障碍的血管生成,导致缺氧和高IFP.
关键的免疫抑制细胞包括髓质衍生抑制细胞 (MDSC),瘤相关巨细胞 (TAM),调节性T细胞 (Tregs) 和癌症相关纤维细胞 (CAF).
这些细胞和血管成分创造了一个免疫抑制的环境,限制了免疫疗法 (例如,免疫检查点抑制剂) 的成功.

结论:

复杂的OC TME,以血管异常和免疫抑制细胞为特征,对有效的癌症治疗构成重大障碍.
旨在使血管系统正常化和调节免疫抑制TME的策略对于改善卵巢癌治疗结果至关重要.
对TME向疗法的进一步研究是有必要的,以提高治疗疗效.

关键词:

免疫抑制是一种免疫抑制.间歇性流体压力之间的压力.卵巢癌是发生在卵巢的癌症.瘤血管新生发生.瘤微环境是一个微环境.血管正常化血管正常化

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