作为甲状腺癌侵袭性特征的预测者,Ki-67标记指数:回顾性分析和影响
Raisa Chowdhury1, Raihanah Alsayegh2,3, Véronique-Isabelle Forest2,3
1Faculty of Medicine, McGill University, Montreal, QC H3G 2M1, Canada.
Current oncology (Toronto, Ont.)
|July 26, 2024
概括
提升的Ki-67标记指数 (LI) 表明甲状腺癌 (TC) 的攻击性. 更高的Ki-67 LI与高风险亚型,淋巴血管入侵和淋巴结转移相关,表明侵入性增加.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- Ki-67免疫染评估了神经内分泌瘤的扩散.
- 它在分类卵泡衍生的甲状腺癌 (TCs) 中的实用性已得到证实.
- 这项研究检查了Ki-67与TCs侵入性的关联.
研究的目的:
- 为了研究Ki-67标记指数 (LI) 与卵泡衍生的甲状腺癌的侵入性之间的关系.
- 为了确定Ki-67 LI是否可以预测甲状腺癌中的攻击性特征.
主要方法:
- 对212名甲状腺癌患者 (2018-2023) 的回顾性分析.
- 收集的数据包括Ki-67 LI,组织学亚型,淋巴血管入侵 (LVI),甲状腺外延伸 (ETE) 和淋巴结 (LN) 转移.
- 统计分析评估了Ki-67 LI和侵袭性标志物之间的关联.
主要成果:
- 更高的Ki-67 LI与高风险组织学亚型有显著的相关性 (p < 0.001).
- Ki-67 LI与LVI (p < 0.001) 和阳性LN转移 (p = 0.036) 有关.
- 一个Ki-67 LI> 6.7%表明具有更高的侵入性特征的可能性.
结论:
- 升高的Ki-67 LI是毛囊衍生的TC中的侵略性的指标.
- Ki-67 LI,特别是当高时,与特定的组织学亚型,LVI和阳性LNs有关,这意味着侵入性增加.
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