伊朗东北部马什哈德的疹病流行病学:一个前性的多中心研究 (2019-2021)
Somayeh Dolatabadi1, Mohammad Javad Najafzadeh2, Abbas Raeisabadi3
1Department of Biology, Hakim Sabzevari University, Sabzevar 9617976487, Iran.
Journal of fungi (Basel, Switzerland)
|July 26, 2024
概括
伊朗的候群病越来越多地是由非白虫Candida物种引起的,Candida parapsilosis是最常见的. 尽管抗真菌耐药性较低,但死亡率仍然很高,这表明治疗和诊断的局限性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 随着流行病学的发展,疹病症对医疗保健构成了重大挑战.
- 非白的Candida (NAC) 种类正在增加,通常表现出抗真菌耐药性.
- 有限的数据存在于像伊朗这样的资源有限的环境中对候病菌物种的分布.
研究的目的:
- 为了调查在伊朗马什哈德的候选病的物种分布,抗真菌耐药性和患者特征.
- 分析与不同Candida物种相关的死亡率.
- 为了评估Candida parapsilosis的潜在医院传播.
主要方法:
- 来自血液培养的酵母分离物被使用MALDI-TOF MS.识别出来.
- 抗真菌敏感性测试 (AFST) 通过微稀释进行.
- 短串重复 (STR) 基因型鉴定应用于Candida parapsilosis分离物.
主要成果:
- 候选菌 (36%) 是最常见的候选血病原因,其次是Candida albicans (33%).
- 总体死亡率为53%,NAC候选症的死亡率比C. albicans (39%) 高 (59%).
- 几乎所有分离物都对抗真菌药物敏感,其中一个C. albicans分离物对anidulafungin有耐药性. STR类型检测显示了C. parapsilosis的集群.
结论:
- 马什哈德的淋病症的特点是C. parapsilosis和C. albicans,可能会导致C. parapsilosis的医院传播.
- 高死亡率与诊断局限性和有限的治疗选择有关,而不是广泛的抗真菌耐药性.
- 对诊断和治疗策略的进一步研究是有必要的,以改善候选血病的结果.
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