遗传多形态和微生物组成与过度饮食障碍的关系:系统性审查
Montserrat Monserrat Hernández1, Diana Jiménez-Rodríguez2
1Department of Geography, History and Humanities, University of Almería, 04120 Almería, Spain.
Healthcare (Basel, Switzerland)
|July 26, 2024
概括
遗传变异和肠道微生物影响过度饮食障碍 (BED) 和强迫性饮食. 最近的研究强调了特定的基因和微生物联系,强调了进一步研究这些生物倾向的必要性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴调节食欲,但遗传因素和饮食会破坏这种电路,导致食物成和腹问题.
- 当传统的心理或营养方法失败时,患者经常寻求过度饮食障碍 (BED) 和强迫性饮食的生物学解释.
研究的目的:
- 审查过去12年 (2012年至今) 的基因和微生物群研究,以确定与BED或强迫性饮食相关的基因和微生物.
- 探索这些饮食障碍背后的生物学倾向,有或没有肥胖.
主要方法:
- 在PRISMA声明之后,进行了一次系统的文献审查.
- 从2012年到现在,搜索了PubMed,PsycINFO,SCOPUS和Web of Science的数据库.
- 分析了24篇国际文章,包括横截面和探索性研究.
主要成果:
- 十九项研究确定了与BED/强迫性饮食相关的遗传多态性,包括DRD2,OPRM1,COMT,MC4R,BNDF,FTO,SLC6A3,GHRL,CARTPT,MCHR2和LRP11.
- 五项研究重点关注微生物组成,表明肠道微生物群在这些疾病中的作用.
- 在过去的四年中,相关研究和潜在标记物的数量显著增加.
结论:
- 遗传多态性和肠道微生物群与暴饮暴食障碍和强迫性饮食有关.
- 进一步的研究至关重要,将遗传,微生物和心理社会因素整合起来,以了解和治疗这些疾病.
- 最近的发现表明,越来越多的证据支持饮食障碍的生物学基础.
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