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患者的特征和长期预后与不同类型的扩展性心肌病的患者

Shuyuan Zhang¹, Shiqi Gao¹, Zhuang Tian¹

¹State Key Laboratory of Complex Severe and Rare Diseases, Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Journal of cardiovascular development and disease

|July 26, 2024

概括

在扩张性心肌病患者中,左心室超化表型增加了早期主要不良心脏事件的风险. 这种表型可能有助于在前五年内识别高风险男性患者.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
预测预测预测预测预测

背景情况:

在中国人群中扩张性心肌病 (DCM) 的预后仍未得到充分研究.
左心室 (LV) 超经常与DCM共存,需要进行预后澄清.

研究的目的:

为了确定LV超化表型是否在DCM患者中提供额外的预后信息.
评估 LV 过度培养对 DCM 中主要不良心脏事件 (MACE) 的影响.

主要方法:

从2002年到2022年对DCM患者 (≥18岁) 的回顾性分析.
基于心声谱的单独DCM (n=353) 与DCM与LV超 (n=97) 的比较.
对MACE的多变量考克斯回归分析.

主要成果:

两组之间总体MACE没有显著差异 (p=0.19).
在前5年中,患有 LV 超结的 DCM 呈现出更高的 MACE 风险 (aHR: 1.83 [1.21-2.77]).
五年后,LV超化的预后影响减弱;显著的性别-DCM亚型相互作用 (p=0.01).

结论:

LV 超化表型与 DCM 患者早期 MACE 风险增加有关.
该表型可能有助于识别高风险的男性DCM患者,特别是在最初的5年内.
对DCM中性别特异性预后因素的进一步研究是有必要的.

关键词:

扩张性心肌病症扩张性心肌病症心脏衰竭是因为心脏衰竭.在左心室中,左心室的超化.预后预后预后

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