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微 (纳米) 塑料暴露诱导的miRNA介导生物毒性研究进展

Ting Chen¹, Qizhuan Lin¹, Changyong Gong¹

¹Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.

|July 26, 2024

概括

微型和纳米塑料 (MNP) 暴露会改变微RNA (miRNA),长非编码RNA (lncRNA) 和圆形RNA (circRNA),可能增加疾病风险. 本综述探讨了MNP生物毒性及其与人类健康问题的联系.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
分子生物学分子生物学

背景情况:

微型和纳米塑料 (MNP) 是广泛存在的环境污染物.
许多MNP可以进入生物体并积聚,造成健康风险.
暴露于MNP与非编码RNAs的改变表达有关.

研究的目的:

审查MNP暴露的生物毒性.
研究失调的microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 在MNP毒性的作用.
突出了解MNP引起的健康风险的挑战和见解.

主要方法:

对MNP暴露和非编码RNA表达研究的文献综述.
分析MNP通过miRNAs,lncRNAs和circRNAs影响基因调节的机制.
检查MNP诱导的毒性影响,包括免疫,神经和细胞功能障碍.

主要成果:

暴露于MNP会改变miRNA,lncRNA和circRNA的表达.
循环RNAs作为miRNA海绵, lncRNAs作为竞争的内源RNAs (ceRNAs) 在响应MNP时起作用.
失调的非编码RNAs有助于线粒体功能障碍,炎症,氧化应激,以及增加神经退行,心血管疾病和癌症等疾病的风险.

结论:

由于MNP暴露而导致的失调的miRNA表达是一种显著的生物毒性问题.
了解这些分子机制对于评估MNP健康风险至关重要.
需要进一步的研究来应对这一领域的挑战,并阐明MNP与疾病的联系.

关键词:

微型和纳米塑料的微和纳米塑料生物毒性生物毒性环RNA 环RNA 是一个环RNA.疾病疾病疾病疾病在ncRNA中,我们可以这是一个小RNARNA.

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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...