微 (纳米) 塑料诱导的编程细胞死亡与疾病风险相关的研究进展
Huanpeng Liu1, Huiqi Li1, Ting Chen1
1Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Toxics
|July 26, 2024
概括
微纳米塑料 (MNP) 污染了生态系统,对包括人类在内的生物造成了伤害. 本综述详细介绍了MNP如何诱导编程细胞死亡 (PCD) 和相关疾病,为缓解策略提供了洞察力.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 微纳米塑料 (MNP) 由于其持久性和污染物吸附,是广泛存在的环境污染物.
- 通过吸入和皮肤接触,MNP进入生物体,在整个食物链中构成风险.
- 有证据表明,MNP会触发被编程细胞死亡 (PCD),并诱导包括人类在内的各种生物体的疾病.
研究的目的:
- 系统地审查MNP诱导的PCD过程.
- 阐明MNP诱导的PCD与疾病之间的联系.
- 讨论与MNP相关的健康风险的治疗干预和缓解策略.
主要方法:
- 关于MNP毒理学和PCD的最新研究的综合文献综述.
- 对MNP对细胞死亡途径的影响的实验和体外研究的分析.
- 综合了MNP诱导的火灭亡,铁灭亡,自灭亡,死灭亡和灭亡的研究结果.
主要成果:
- 许多MNP诱导多种形式的PCD,包括热,铁,自,死和亡.
- 特定的PCD途径与MNP暴露引起的各种疾病有关.
- 目前的研究提供了对MNP诱导病理的潜在治疗干预措施的见解.
结论:
- 了解MNP诱导的PCD对于评估健康风险至关重要.
- 有针对性的疗法可以减轻因MNP暴露而引起的疾病.
- 本次审查是未来毒理学研究和MNP风险管理的参考.
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