在一般人群中暴露于内分泌干扰化学物质和神经认知功能:基于社区的研究
Feng-Chieh Su1,2, Yi-Chia Wei1,3,4, Chiao-Yin Sun2,4,5
1Department of Neurology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Toxics
|July 26, 2024
概括
暴露于内分泌干扰化学物质 (EDCs),特别是单二乙甲酸 (MEHP),与老年人的认知能力下降有关. 较高的MEHP水平与神经认知障碍的风险增加有关.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 内分泌干扰化学物质 (EDC) 是广泛存在的环境污染物.
- EDCs对神经认知功能的影响尚未完全理解.
研究的目的:
- 调查EDC暴露与老年人认知障碍之间的关联.
- 确定与神经认知衰退相关的特定EDC.
主要方法:
- 887名参与者的横截面研究,根据EDC暴露对120名个人进行了详细分析.
- 在67名老年人 (≥55岁) 中使用确定的痴呆症-8 (AD-8) 问卷评估认知功能.
- 分析与AD-8分数相关的单二乙烯甲酸 (MEHP) 含量.
主要成果:
- 较高的MEHP水平与认知障碍 (AD-8 ≥2) 的风险增加显著相关.
- 经过调整的统计模型显示MEHP水平与AD-8分数之间存在正相关性 (p=0.042).
- 后勤回归表明,高MEHP和更高的AD-8分数 (OR=1.217,p=0.006) 之间存在显著的正相关性.
结论:
- 暴露于MEHP的前体二甲基甲酸,可能与神经认知障碍有关.
- 研究结果表明EDC在与年龄相关的认知衰退中的潜在作用.
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