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体重指数对患有大动脉狭窄的糖尿病患者死亡率的影响
Kai-Chun Chang1, Li-Ting Ho1,2, Kuan-Chih Huang3
1Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Aging
|July 26, 2024
概括
在患有大动脉狭窄的糖尿病患者中,体重不足增加了死亡风险,而肥胖与更好的心血管结果有关,挑战了对肥胖的典型看法. 这突出了人体质量指数和这一群体的生存率之间的复杂关系.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 肥胖悖论表明,某些疾病的肥胖个体的结果更好.
- 2型糖尿病 (DM) 和大动脉狭窄 (AS) 是常见的并发症.
- 身体质量指数 (BMI) 对AS的DM患者死亡率的影响需要进一步调查.
研究的目的:
- 调查BMI与2型糖尿病患者和大动脉狭窄症患者的死亡率之间的关联.
- 根据BMI类别,探索不同的死亡风险 (心血管和非心血管).
主要方法:
- 分析了2014年至2019年期间接受心声回声扫描的74,835名患有DM的患者.
- 被归类为体重不足 (<18.5公斤/米2),体重正常 (18.5-27公斤/米2) 或肥胖 (>27公斤/米2) 的患者.
- 评估的结果包括6年随访期间的全因,心血管和非心血管死亡率.
主要成果:
- 体重不足患者 (4.1%) 的全因死亡率显著增加 (HR 1.96).
- 与正常体重患者相比,肥胖患者 (30.4%) 的全因死亡率 (HR 0.79) 显著降低.
- 体重不足与非心血管死亡的增加有关 (HR 2.47),而肥胖与心血管死亡的减少有关 (HR 0.66).
结论:
- 体重指数显著影响糖尿病患者的死亡风险,有大动脉狭窄.
- 体重不足状态是较差非心血管生存的预测因素.
- 肥胖似乎与这种特定患者队列中心血管存活率的改善有关.
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