活性蛋白A促进了致病性多细胞因子IL-9分泌的CD4+T细胞群体的分化
Benjamin J Ulrich1, Wenwu Zhang1, Blake T Kenworthy1
1Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN.
Journal of immunology (Baltimore, Md. : 1950)
|July 26, 2024
概括
活性蛋白A和TGF-β诱导介素-9 (IL-9) 产生T辅助细胞9 (Th9). 活性蛋白A产生多种类型的Th9细胞,与TGF-β不同,影响过敏性炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 辅助T (Th) 细胞的分化是由炎症信号和细胞因子指导的.
- Th9细胞的特征是分泌互白素-9 (IL-9),在免疫,过敏和自身免疫方面发挥作用.
- 转化生长因子-β (TGF-β) 和互白素-4 (IL-4) 促进IL-9的产生,但TGF-β家族成员在Th9细胞发育中的独特作用尚不清楚.
研究的目的:
- 调查TGF-β和活性A是否产生具有相同表型和功能的Th9细胞.
- 为了比较TGF-β和Activin A对Th9细胞分化和细胞因子产生的影响.
主要方法:
- 用TGF-β或Activin A与IL-4结合使用鼠Th9细胞培养物进行了差异化.
- 分析了差异化Th9细胞的细胞因子生产概况.
- 评估了差异化Th9细胞促进过敏炎症的能力.
主要成果:
- 与TGF-β不同的是,与activin A的分化导致了多细胞因子T细胞表型,在IL-9之外分泌IL-4,IL-5,IL-13和IL-10.
- 在小鼠Th9培养物中,TGF-β有效抑制了Th2细胞因子.
- 由activin A产生的多种细胞因子分泌的Th9细胞在促进过敏炎症方面更有效.
结论:
- TGF-β和活性蛋白A诱导具有不同细胞因子配置和功能能力的独特Th9细胞群.
- 活性蛋白A促进一种分泌多种细胞因子的Th9细胞表型,增强过敏性炎症.
- 这些发现表明,TGF-β和IL-4以外的细胞因子线索可能对免疫和疾病中的最佳IL-9产生T细胞功能至关重要.
相关概念视频
T Cell Activation and Clonal Selection
693
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
693
T Cell Types and Functions
967
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
967
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Cells of the Adaptive Immune Response
972
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
972
TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K


