高血压会扰乱两性人的血管时钟
Bruna Visniauskas1, Benard O Ogola1,2, Isabella Kilanowski-Doroh1
1Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States.
概括
高血压破坏了男性和女性的血压节奏和血管钟基因. 观察到对活动,心率和巴罗反射灵敏度的性别特异性影响,突出了昼夜生物学与心血管健康之间的联系.
科学领域:
- 心血管生理学心血管生理学
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
背景情况:
- 循环节律调节血压 (BP),并且干扰会增加心血管风险.
- 血管钟基因在血压调节中的作用和性别差异尚未完全理解.
- 众所周知, ангиотензин II (ANG II) 诱导的高血压会影响血压和血管功能.
研究的目的:
- 在ANG II诱导的高血压期间调查昼夜节律和血管钟基因表达的性别差异.
- 为了确定高血压是否对血压,血管反应和性别之间的时钟基因模式产生差异性影响.
- 探索性,昼夜生物学和高血压在心血管调节中的相互作用.
主要方法:
- 利用注入血管新生二 (ANG II) 的小鼠模型诱导高血压.
- 在雄性和雌性小鼠中监测血压 (BP),心率 (HR),运动运动活动和巴罗反射灵敏度 (BRS).
- 分析了关键血管钟基因 (Per1,Bmal1) 和雌激素受体 (Gper1,Esr1) 的日间表达模式.
主要成果:
- 在两性中,ANG II输液使血压升高,并以同样的方式扰乱昼夜模式.
- 高血压影响了女性的HR和活动,男性的BRS.
- 对Per1,Bmal1和Gper1的血管表达显示了两性中高血压扰乱的白天模式;Esr1显示了性别特定的白天调节和扰乱.
结论:
- 高血压同样破坏了男性和女性小鼠的血压节奏和血管钟基因表达.
- 观察到性别特异性心血管对高血压的反应,包括HR,活动和BRS的差异.
- 研究结果揭示了昼夜生物学,性别和心血管调节之间的复杂联系,这表明了性别特定的慢性治疗策略的潜力.
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