针对ER-阳性乳腺癌的初始分期和疑似复发的ER-向PET
Gary A Ulaner1,2, Mel Silverstein3, Chaitali Nangia4
1Molecular Imaging and Therapy, Hoag Family Cancer Institute, Irvine, California.
JAMA network open
|July 26, 2024
概括
与检测雌激素受体阳性乳腺癌转移的标准护理成像相比,16α-18F--17β-雌激醇 (FES) PET/CT没有显著差异. 需要对叶片瘤和减少虚假阳性进行进一步的研究.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 核医学就是核医学.
背景情况:
- 标准护理成像 (SOC) 缺乏与16α-18F--17β-雌激醇 (FES) 定子发射断层扫描 (PET) /计算机断层扫描 (CT) 对局部晚期乳腺癌 (LABC) 的分期和评估疑似复发的可靠比较数据.
- 雌激素受体 (ER) 阳性乳腺癌复发和LABC分期需要精确检测远程转移.
研究的目的:
- 为了比较FES PET/CT和SOC成像对ER阳性LABC中远程转移的检测率.
- 评估FES PET/CT和SOC成像检测率,以检测ER阳性乳腺癌患者怀疑复发的情况.
主要方法:
- 一个单一中心的第二阶段诊断研究,从2021年1月到2023年9月进行.
- 124名ER阳性LABC或疑似复发的患者接受了SOC成像和FES PET/CT.
- 组织病理活检作为可疑病变的参考标准来确定真假阳性.
主要成果:
- 在LABC (11对12) 或复发 (18对16) 中远程转移的FES PET/CT和SOC成像检测率没有显著差异.
- 在球状组织学患者中,FES PET/CT检测出比SOC成像检测更多的真实阳性结果 (9对5).
- 与SOC成像相比,FES PET/CT显示了较少假阳性 (1对6) 的趋势.
结论:
- 在检测ER阳性LABC和疑似复发的远程转移方面,FES PET/CT的疗效与SOC成像学相美.
- 尽管它不是当前适当使用标准的一部分,但FES PET/CT可能会被考虑用于这些适应症.
- 在叶状乳腺癌和其较低的错误阳性率中,FES PET/CT的潜在益处需要进一步研究.
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