暴露于环境热量和自发流产风险:一个案例交叉研究
Amelia K Wesselink1,2, Emma L Gause2, Keith R Spangler2,3
1From the Department of Epidemiology, Boston University School of Public Health, Boston, MA.
Epidemiology (Cambridge, Mass.)
|July 26, 2024
概括
高室外温度与自发流产风险增加有关. 这项研究发现了一个U形的关联,在温暖的月份和极端高温暴露期间风险增加.
科学领域:
- 环境流行病学环境流行病学
- 生殖健康 生殖健康
- 围产期结局的结果
背景情况:
- 自发流产是一种常见的妊娠并发症.
- 关于环境热量对自发流产风险的影响的研究有限.
研究的目的:
- 调查室外空气温度与自发流产风险之间的关联.
- 检查不同季节的温度相关风险.
主要方法:
- 一个在预孕队列中嵌入的案例交叉研究 (在线怀孕研究,2013-2022).
- 包括1524个自发堕胎案例.
- 分析了事件发生前7天的温度数据 (平均值,最大值,最小值,每日最大值),使用条件后勤回归.
主要成果:
- 在室外温度和全年自发流产风险之间观察到U形的关联.
- 在温暖的季节,平均每日最高气温的第10百分点增加显示OR为1.1 (95%CI:0.96,1.2).
- 在前一周暴露于极端炎热的日子 (>95百分位数) 与OR为1.2 (95% CI:0.95,1.5) 相关.
结论:
- 高环境温度与自发流产的发生率增加有关.
- 这些发现突出了气候对怀孕早期结果的潜在影响.
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