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Updated: Jun 19, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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确定 Ku 在染色质积累的主要障碍

Madeleine Bossaert1, Andrew T Moreno2, Antonio Peixoto1

  • 1Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), Toulouse, France; Equipe Labéllisée la Ligue contre le Cancer 2018.

Cell reports
|July 26, 2024
PubMed
概括

在DNA断裂时限制Ku蛋白加载的机制可以防止基因组不稳定. DNA-PKcs,内滴化/FBXL12和CtIP/ATM通路限制Ku的积累,保持在DNA修复部位附近的正常基因转录.

关键词:
这是一个ATMATMATM.科普:分子生物学 分子生物学CtIP 的意思是"共同的知识产权".在DNA末端的切除过程中,修复DNA的修复DNA的修复这就是DNA-PKK.这就是DNA-PKcscs.在FBXL12上.在这里,你会看到很多东西.人类 MRN 的人类 MRN尼希耶 (NHEJ) 是一个这是Xenopus.没有脱,没有脱.

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