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提高四水库作为抗癌剂的可溶性和功效,使用β-环氧德克斯含复合体方法

Zhi Xuan Low¹, Michelle Yee Mun Teo¹, Fariza Juliana Nordin²

¹Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.

|July 26, 2024

概括

一种使用β-cyclodextrin (βCD) 的新型药物递送系统改善了四水库明 (THC) 的溶解性和抗癌效果. 这种配方在临床前模型中增强了瘤回归和降低了毒性,显示了结直肠癌治疗的前景.

科学领域:

药理学药理学是指药理学的学科.
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

黄中的库尔库米诺酸具有抗癌潜力,但具有不良的溶解性和低生物利用性.
现有的局限性阻碍了黄素衍生物在癌症治疗中的治疗应用.
开发有效的药物输送系统对于克服这些挑战至关重要.

研究的目的:

开发一种新的有机基药物输送系统,用于使用β-cyclodextrin (βCD) 的四水库 (THC).
为了提高THC的水性分散,生物可用性和抗癌功效.
评估THC-βCD纳入复合物的体外和体内性能,用于结直肠癌 (CRC) 治疗.

主要方法:

使用UV-vis,DSC,FTIR和SEM进行THC-βCD纳入复合物的物理化学表征.
在体外细胞毒性测定和亡,迁移和入侵率评估.
在体内对无血性裸体小鼠进行研究,以评估瘤回归,全身毒性 (H&E染色) 和血清瘤标志物水平 (CEA,CYP1A2).

主要成果:

通过THC-βCD纳入复合体,水性分散率增加了65倍,药物含量增加.
在体外和体内研究表明显著的抗癌作用,包括瘤回归,增强的亡,减少迁移/入侵.
该配方显示系统毒性降低,血清瘤标志物 (CEA,CYP1A2) 减少,与瘤体积减少相关.

结论:

开发的THC-βCD纳入复合物显著提高了疏水性库尔库米诺酸的溶解性和治疗潜力.
这种新的配方提供了一种有前途的策略,通过改善药物输送和降低毒性来增强结直肠癌化疗.
这项研究强调了基于βCD的系统在增强难溶性抗癌剂的潜力.

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