视力障碍与老年人痴呆和精神病遗传风险之间的相互作用
Ali G Hamedani1,2,3, Colin A Ellis1, Joshua R Ehrlich4,5
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Age and ageing
|July 26, 2024
概括
视力障碍与痴呆和抑郁症有关,但不能由共同的遗传学解释. 然而,视力障碍强烈地预测了精神分裂症遗传风险高的个体的幻觉.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 眼科医生 眼科 眼科
背景情况:
- 视力障碍 (VI) 是痴呆症和其他神经精神疾病的已知风险因素.
- 以前的研究还没有充分探索影响这些关联的遗传因素.
研究的目的:
- 调查视力障碍与痴呆症,抑郁症和幻觉之间的联系.
- 检查遗传风险因素,包括多基因风险评分 (PRS) 在混或修改这些关联中的作用.
主要方法:
- 从健康和退休研究 (n=13,465) 分析数据,包括遗传测试.
- 使用比例危险模型和通用估计方程来评估关联.
- 对阿尔茨海默病,严重抑郁症和精神分裂症的人口统计,并发病,祖先和PRS进行调整.
主要成果:
- 视力障碍与痴呆症,抑郁症和幻觉有关,即使在调整遗传风险因素后也是如此.
- 对于痴呆症或抑郁症,视力障碍和PRS之间没有发现显著的相互作用.
- 观察到视力障碍和精神分裂症 (PRS) 与幻觉之间存在显著的相互作用;这种联系在具有最高遗传风险的个体中最为强烈.
结论:
- 共同的遗传因素不能解释视力障碍与痴呆或抑郁症之间的联系.
- 视力障碍显著增加了幻觉的风险,特别是在精神分裂症的高多基因风险的人群中.
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