在接受免疫调节治疗的AZOOR病例
David A Merle1,2,3, Lasse Wolfram1,2, Emil Nasyrov1
1Department for Ophthalmology, University Eye Clinic, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Retinal cases & brief reports
|July 26, 2024
概括
本案例报告详细介绍了急性区域隐形外视网膜病变 (AZOOR) 的治疗方法. 普雷迪尼索隆和阿达利穆马布的联合治疗有效地阻止了双边AZOOR患者的疾病进展.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
背景情况:
- 急性区域隐形外视网膜病变 (AZOOR) 呈现出不特定的症状,使诊断复杂化.
- 对于AZOOR存在许多差异诊断,需要进行彻底的调查.
研究的目的:
- 记录诊断为AZOOR的患者的临床过程和治疗结果.
- 评估联合免疫抑制疗法在治疗AZOOR治疗中的有效性.
主要方法:
- 使用全面的眼科检查进行的观察病例报告.
- 进行了纵向多式成像,视野测试和电生理学记录.
- 进行了血清学分析和全基因组测序,以排除其他病因.
主要成果:
- 一名33岁的女性呈现双边AZOOR,排除了其他原因.
- 最初的口服普雷迪尼索隆提供了暂时的控制,但在停止治疗后疾病复发.
- 一种治疗方案的逐渐缩小的口服普雷迪尼索隆与阿达利木马布结合,实现了持续的疾病控制超过21个月.
结论:
- 准确的AZOOR诊断需要通过广泛的工作来排除差异诊断.
- 经验性治疗策略是必要的,因为没有随机对照试验.
- 密切跟踪对于管理AZOOR患者至关重要.
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