低血瘤缩因子-α与精神分裂症患者的症状缓解有关
Ryo Asada1, Hikaru Hori1, Leo Gotoh1
1Department of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1, Nanakuma, Jyonan-ku, Fukuoka city, Fukuoka, 8140180, Japan.
Journal of psychiatric research
|July 26, 2024
概括
与对照组相比,精神分裂症缓解期患者的血瘤缩因子-α (TNF-α) 水平较低. 这些TNF-α水平与认知或社会功能无关,这表明它有可能作为缓解的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症是一种复杂的精神疾病.
- 瘤坏死因子-α (TNF-α) 与神经炎症有关.
- 需要用于精神分裂症缓解的生物标志物.
研究的目的:
- 为了比较精神分裂症患者缓解期与健康对照者的血TNF-α水平.
- 研究血TNF-α水平与精神分裂症的认知和社会功能之间的关联.
主要方法:
- 对48名精神分裂症缓解患者和20名健康对照者的横截面研究.
- 血TNF-α水平通过酶相关免疫吸收试验测量.
- 使用精神分裂症认知简要评估 (日本版,BACS-J) 评估认知功能.
- 使用社会功能表 (SFS-J) 评估的社会功能.
主要成果:
- 血TNF-α水平在精神分裂症缓解组 (31.7 ± 27.4 ng/mL) 与健康对照组 (55.1 ± 38.5 ng/mL) 相比显著较低 (P = 0.01).
- 在两组中,血TNF-α水平和BACS-J或SFS-J得分之间没有发现显著的相关性.
结论:
- 较低的血TNF-α水平可能表明精神分裂症缓解.
- 血TNF-α水平与这种队列中的认知或社会功能无关.
- TNF-α显示出作为精神分裂症治疗反应的生物标志物的潜力.
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