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在叶手术后出现De novo抑郁症

Jacint Sala-Padro¹, Myriam De la Cruz-Puebla², Júlia Miró¹

¹Epilepsy Unit, Hospital Universitari de Bellvitge, Spain; Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08097, Spain.

|July 26, 2024

概括

时间叶 (TLE) 手术可能导致抑郁症. 手术后海马 - 核 Accumbens 连接性减少可能预测 TLE 患者的 de novo 抑郁症 (DnD).

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

(TLE) 手术有效治疗耐药性.
手术后情绪障碍,特别是新型抑郁症 (DnD),是令人担忧的,特别是在没有先前精神病史的患者中.
了解连接TLE,手术和情绪障碍的神经机制对于患者护理至关重要.

研究的目的:

调查TLE,新型抑郁症 (DnD) 和海马体 (Hipp) 和核 (NAcc) 的功能连接之间的关系.
确定潜在的神经成像生物标志物,用于预测TLE患者手术后的DnD.

主要方法:

病例控制研究涉及27名TLE患者和18名对照人群.
手术前后的结构性和功能性MRI扫描.
分析Hipp和NAcc之间的功能连接,比较患有DnD和没有DnD的患者.

主要成果:

在27名TLE患者中,有7人在手术后一年内发展出DnD.
88.8%的患者与对照人群相比,NAcc-Hipp连接性降低.
DnD组的NAcc-Hipp连接性明显低于非抑郁 (nD) 组.
在ROC分析中,发现了一个潜在的生物标志物值 (克劳福德-T值为-2.08),灵敏度为0.83和特异性为0.76.

结论:

在TLE患者手术后,奖励网络中的功能连接,特别是海马和腹核之间的功能连接发生了变化.
减少Hipp-NAcc连接性可能成为TLE患者新型抑郁症 (DnD) 的预测生物标志物.
识别有风险的个体可以改善接受手术的TLE患者的治疗指导和临床决策.

关键词:

抑郁症抑郁症抑郁症的手术手术是在.功能性的连接性功能性的连接性单个主题的单个主题.

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