青春期前的语言下免疫疗法在过敏性鼻炎和喘中比青春期的免疫疗法更有效
Yongjun Zhu1, Lin Yan1, Nan Cheng1
1Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
American journal of otolaryngology
|July 26, 2024
概括
语言下特异性免疫疗法 (SLIT) 有效治疗儿童过敏性鼻炎和喘. 这种治疗改善了症状和肺功能,在年轻的青春期前儿童中显示出更好的结果.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 免疫治疗是一种免疫疗法.
背景情况:
- 过敏性鼻炎和喘在儿童中很常见.
- 亚语言特异性免疫疗法 (SLIT) 是一种治疗选择.
- 评估SLIT在不同年龄组 (包括青春期) 的疗效至关重要.
研究的目的:
- 评估亚语言特异性免疫疗法 (SLIT) 在过敏性鼻炎和喘儿童的临床有效性.
- 在SLIT期间评估青春期前后肺功能变化.
- 为了比较青春期前和青春期儿童之间的治疗结果.
主要方法:
- 对136名患者 (4-18岁) 的回顾性分析,接受了2年的SLIT.
- 患者分为青春期前 (4-10岁) 和青春期 (11-18岁) 的两组.
- 评估了0.5年,1年和2年的症状评分,药物使用,喘控制 (ACT) 和最大呼气流量率 (PEF%).
主要成果:
- 在SLIT后,在两组中都观察到鼻腔和喘症状,药物评分和肺功能 (PEF%) 的显著改善.
- 青春期前的儿童在鼻腔症状和喘药物评分方面表现出更好的初始反应.
- 与青春期儿童相比,青春期前儿童的肺功能 (PEF%) 在青春期前儿童中得到更显著的改善.
结论:
- 语言下特异性免疫疗法 (SLIT) 有效控制了儿童过敏性鼻炎和喘症状.
- SLIT减少了对症状药物的需要,并改善了肺功能.
- 与青少年相比,SLIT在青春期前儿童的喘控制上表现出更明显的积极作用.
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
264
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
264
Drugs Used in Lower Respiratory Disorders: Overview
386
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
386
Antiasthma Drugs: Leukotriene Modifiers
268
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
268
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
259
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
259
Allergic Reactions
27.3K
Overview
27.3K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
233
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
233


