免疫疗法的疗效和毒性:审查患者可实施策略背后的证据
Marthe August Marianne Verhaert1, Sandrine Aspeslagh2
1Department of Medical Oncology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium.
European journal of cancer (Oxford, England : 1990)
|July 26, 2024
概括
免疫检查点抑制剂 (ICI) 改善了癌症治疗,但有免疫相关不良事件 (irAEs) 的风险. 肠道微生物组和生活方式因素影响irAEs,为缓解策略提供目标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗,改善结果,但引起与免疫相关的不良事件 (irAEs).
- 了解影响irrAEs的因素对于患者的管理和治疗坚持至关重要.
- 肠道微生物组和生活方式选择正在成为影响irAE风险的显著可修改因素.
研究的目的:
- 审查目前关于肠道微生物组在irAEs发生中的作用的证据.
- 识别和评估可行的策略,以减轻irAEs.
- 为在各种瘤环境中管理免疫治疗相关的毒性提供见解.
主要方法:
- 文献综述整合了关于肠道微生物组和irAEs的证据.
- 分析可修改因素,包括饮食,补充剂,药物和身体活动.
- 综合目前关于生活方式干预措施的研究,以减少irAE风险.
主要成果:
- 肠道微生物组的组成与irAEs的发展有关.
- 有证据支持饮食调整,补充剂,药物管理和体育活动作为潜在的缓解策略.
- 可修改的生活方式因素提供了一个有希望的途径,通过减少毒性来增强免疫治疗结果.
结论:
- 肠道微生物组显著影响与免疫检查点抑制剂相关的免疫相关不良事件.
- 改变生活方式是缓解irAEs和改善患者生活质量的可行方法.
- 对微生物向和生活方式干预的进一步研究是有必要的,以优化癌症免疫疗法.
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