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Xin-Yan Yao¹, Bo-Wen Shi², He-Ping Li³

¹Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan province, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan, China; School of Life Science and Engineering, Foshan University, Foshan, 528225, Guangdong province, China.

|July 26, 2024

概括

猫类口腔病毒 (FBoV) 在哈尔的健康猫群中传播,检测到基因型1和3. 基因组分析揭示了重组和负选择,突出了FBoV.

科学领域:

兽医病毒学兽医病毒学
分子流行病学分子流行病学

背景情况:

猫口腔病毒 (FBoV) 是一种影响家猫的广泛病原体.
目前尚不完全了解FBoV的全致病潜力和遗传多样性.
全球FBoV的分布需要进一步的流行病学和进化研究.

研究的目的:

在哈尔的健康猫群中调查FBoV的流行率和遗传特征.
为了识别循环的FBoV基因型并检测遗传重组事件.
分析塑造FBoV基因组的进化压力.

主要方法:

从哈尔的健康猫收集和分析了289个血液样本.
对FBoV菌株的分子检测和基因定型.
生物信息分析以确定重组事件和选择压力.

主要成果:

在研究的猫群中检测到12.1%的FBoV总流行率.
发现FBoV基因型1和3的同时循环.
在新型菌株 (NG/104,DL/102) 中发现了重组事件,编码基因中普遍存在负选择.

结论:

在哈尔的猫群中,基因多样化的FBoV菌株共同循环.
净化选择是FBoV基因组进化的主要驱动力.
持续的监测对于了解FBoV流行病学和演变至关重要.

关键词:

猫类口腔病毒猫类口腔病毒遗传多样性遗传多样性净化选择的选择.再组合的重组方式

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