在精神分裂症谱系障碍患者中,基于全血细胞计的炎症指数和症状严重程度:基于结构方程建模的分析
Daniele Cavaleri1, Aldo De Pietra1, Marco Gazzola1
1School of Medicine and Surgery, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy.
Psychoneuroendocrinology
|July 26, 2024
概括
单细胞与淋巴细胞比率 (MLR) 与精神分裂症谱系障碍 (SSD) 的症状严重程度有关. 这项研究发现MLR,但不是NLR或PLR,与SSD患者的积极和消极症状相关.
科学领域:
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 精神分裂症谱系障碍 (SSD) 涉及免疫-炎症激活.
- 基于全血细胞计 (CBC) 的炎症指数,如中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和血小板与淋巴细胞的比率 (PLR) 是精神疾病的新兴生物标志物.
- 这些CBC比率提供了一种可复制和具有成本效益的方法来评估炎症.
研究的目的:
- 调查NLR,MLR和PLR之间的关系以及SSD患者的症状严重程度.
- 检查这些炎症标志物和临床变量 (如物质使用障碍,抗精神病治疗和肥胖症) 之间的潜在相互作用.
主要方法:
- 包括266名年龄在18-65岁之间的SSD住院患者.
- 记录社会人口和临床数据,包括物质使用障碍,抗精神病治疗和肥胖症.
- 从常规血液样本和使用结构方程建模 (SEM) 的分析中估计基于CBC的比率 (NLR,MLR,PLR).
主要成果:
- 结构方程建模揭示了MLR和两者之间的显著关联正 (coeff. : 0.19,p=0.048) 和负值 (系数) 的情况. : 0.27,p=0.004) 在SSD患者的症状.
- 药物使用障碍和抗精神病治疗与症状严重程度有显著的联系.
- 抗精神病治疗也显示出与肥胖有显著的关联.
结论:
- 与NLR和PLR不同的是,MLR与SSD中阳性和阴性症状的严重程度有显著的关系.
- 该研究强调了MLR作为SSD症状严重程度的生物标志物的潜在作用.
- 建议进行进一步的研究以验证这些发现,并探索由于横截面设计和样本限制的潜在机制.
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