产前母性皮质醇与学前内部化问题之间的纵向关系
Lars Meinertz Byg1, Niels Bilenberg2, Dorte Glintborg3
1School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia; Child and Adolescent Mental Health Southern Denmark, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.
Psychoneuroendocrinology
|July 26, 2024
概括
考虑到其他因素后,母亲的产前皮质醇水平与男孩或女孩的童年情绪问题没有联系. 出生体重没有调解这种关联,这表明皮质醇不能预测以后的内化行为.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 发展心理学 发展心理学
- 内分泌学 在内分泌学.
背景情况:
- 产前接触合成皮质糖类药物与儿童情绪症状有关.
- 怀孕期间母亲的皮质醇水平可能会影响胎儿的发育和随后的行为.
- 了解母亲的压力荷尔蒙与儿童内化问题之间的关系至关重要.
研究的目的:
- 调查第三季度母亲血清皮质醇与子女学前年龄内化问题的关联.
- 检查出生体重是否调解母亲皮质醇和儿童内化问题之间的关系.
- 为了探索这种协会中潜在的性别差异.
主要方法:
- 前性队列研究 (奥登斯儿童队列,n=1162) 包括母体皮质醇,出生体重和儿童行为检查清单 (CBCL) 数据.
- 线性混合模型被用来评估关联,按后代的性别分层.
- 共同变量包括父母的精神病史,平价,产妇年龄,教育,吸烟和妊娠年龄.
主要成果:
- 原始分析显示,母亲的皮质醇与男孩和女孩的内化问题之间存在积极的关联.
- 经过调整后的分析显示,母体皮质醇与子女内化问题在两性之间没有统计学上显著的关联 (p > 0.15).
- 出生体重并没有调解母亲皮质醇与内化问题之间的关系.
结论:
- 在调整混因素后,母亲的第三个三个月的皮质醇水平并不能预测学龄前后代的内部化问题.
- 在原油分析中观察到的初始关联没有持续,表明其他因素的作用.
- 研究结果表明,怀孕后期的生理母亲皮质醇水平并不能预测幼儿时期内化问题.
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