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在移植的多能干细胞衍生的心肌细胞中启动脉冲可以刺激接受心脏

Tim Stüdemann1, Barbora Schwarzová1, Till Schneidewind1

  • 1Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Germany.

Stem cell reports
|July 26, 2024
PubMed
概括

移植的干细胞衍生的心肌细胞可以与宿主心脏电气连接和节奏. 这项研究表明,这些细胞如何引发心律失常,这是心力衰竭治疗的关键安全问题.

关键词:
节律失常 节律失常心脏再生心脏再生这是心肌细胞 (cardiomyocyte).细胞治疗疗法细胞治疗疗法视觉遗传学 视觉遗传学干细胞是一种干细胞.

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...