第二种原发性肺癌 - - 肺癌幸存者的新兴问题
Sarah Østrup Jensen1, David A Moore2, Arif A Surani1
1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.
概括
改善的肺癌存活率导致更多的第二原发性肺癌 (SPLC). 早期检测和准确的诊断,包括基因组分析和生物标志物,对于在幸存者中管理SPLC至关重要.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 遗传学 是一个遗传学.
背景情况:
- 通过早期检测和更好的治疗,提高肺癌5年生存率.
- 增加的生存率带来了挑战,包括幸存者患第二原发性肺癌 (SPLC) 的风险更高.
- 新出现的数据表明,SPLC的发病率可能被低估,可能会在5年内影响6名幸存者中的1人.
研究的目的:
- 审查第二次原发性肺癌 (SPLC) 监测,诊断和管理方面的挑战.
- 突出SPLC与肺内转移的区别的重要性,以确保适当的患者管理.
- 探索新兴的 SPLC 检测和分类的基因组和生物标记方法.
主要方法:
- 对最近关于SPLC发病率的前性后续研究的审查.
- 检查当前和新兴的诊断技术,包括基因组分析.
- 讨论临床病史,组织病理学评估,以及用于SPLC识别的基于血液的生物标志物.
主要成果:
- SPLC的发病率可能比以前认为的要高,与多焦点腺癌谱系疾病有关.
- 精确区分SPLC和复发是至关重要的,因为管理策略有很大的不同.
- 基因组方法显示SPLC与转移的区分有前途,尽管尚未成为常规.
结论:
- 需要更新的分类方法,结合临床,组织病理学和基因组数据,用于SPLC.
- 早期检测生物标志物,特别是基于血液的生物标志物,需要进一步调查,以在幸存者中确定SPLC.
- 解决SPLC挑战对于改善日益增长的肺癌幸存者人口的长期结果至关重要.
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