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Updated: Jun 19, 2025

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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在线细胞衰变过程中,TNIP1与FIP200结合的结构基础.

Shengmei Wu1, Mingwei Li2, Lei Wang1

  • 1Hefei National Research Center for Cross Disciplinary Science, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Ministry of Education Key Laboratory for Membraneless Organelles and Cellular Dynamics, University of Science & Technology of China, Hefei, Anhui, China; Division of Life Sciences and Medicine, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China, Hefei, Anhui, China.

The Journal of biological chemistry
|July 26, 2024
PubMed
概括

TBK1对TNIP1的酸化增强了它与FIP200的结合,这是调节线粒的关键步骤. 这项研究揭示了FIP200如何发挥作用.

关键词:
在TNFAIP3相互作用蛋白1 (TNIP1) 中.晶体结构 晶体结构200 kDa (FIP200) 的焦粘附激酶 (FAK) 相互作用蛋白 (FIP200)线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.酸化的方法是:光化.

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