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Updated: Aug 14, 2026

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
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Published on: January 20, 2023

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从冷保护剂和缓冲查中对冷化mRNA-LNP的物理化学和结构见解

Yuchen Fan1, Diamanda Rigas2, Lee Joon Kim3

  • 1Synthetic Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Journal of controlled release : official journal of the Controlled Release Society
|July 26, 2024
PubMed
概括

淋化可以稳定信使RNA-脂质纳米粒子 (mRNA-LNP) 疗法,消除超冷储存需求. 新型辅助剂,如聚烯利 (PVP),有望提高mRNA-LNP的稳定性和功能.

关键词:
在体外活动中的体外活动.天生的免疫反应.软化液化化是什么意思物理化学属性 物理化学属性结构与活动的关系.在 mRNA-LNP 之间.

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