父母和孩子之间的长期持久性患者报告的埃索诺菲尔性食道炎的结果
Lisa J Martin1, Xue Zhang2, Mirna Chehade3
1Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati College of Medicine, Cincinnati, Ohio.
The Journal of allergy and clinical immunology
|July 26, 2024
概括
父母和孩子对性食道炎 (EoE) 症状的报道显示,随着时间的推移,他们之间存在强烈的共识. 这证实了家长报告的结果是可靠的评估儿科EoE,即使在长期研究.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床研究方法论临床研究方法论
- 患者报告的结果 (PROs)
背景情况:
- 患有性食道炎 (EOE) 的儿童无法自我报告症状,需要父母代孕报告.
- 以前的研究表明,EoE PROs的父子对齐,但纵向稳定性仍然不清楚.
研究的目的:
- 评估EOE儿童与其父母之间的PROs的一致性和纵向稳定性.
- 评估家长报告的可靠性作为儿科EoE症状的代理.
主要方法:
- 这是一项为期五年的观察性试验,涉及292个亲子对象,他们填写了723个问卷.
- 使用相关性和布兰德-阿尔特曼分析评估了儿科埃索诺菲尔食道炎症状评分版本2 (PEESSv2.0) 和PedsQL-EoE的一致性和变化.
- 利用线性混合模型来评估影响PRO及其协议的临床因素.
主要成果:
- 在PEESSv2.0 (0.83) 和PedsQL-EoE (0.74) 的儿童和家长报告之间观察到强烈的相关性.
- 父母报告的PedsQL-EoE得分在纵向上保持稳定,而儿童报告的得分有所改善.
- 在PedsQL-EoE报告中,较大的差异与年龄较小有关,并由心理社会领域驱动.
结论:
- 对于EoE PROs,儿童和家长报告之间存在显著的纵向对齐.
- 父母报告作为客观的EOE儿童症状评估的稳定和可靠的代理.
- 调查结果支持在长期儿科EdE管理和研究中使用家长报告的结果.
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