相关实验视频

Updated: May 6, 2026

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Published on: December 28, 2010

用间歇性甲型爆发波形进行神经磁性神经调节,可增强膀过度活动:体内实验室研究

Nurida Khasanah¹, Hung-Yen Chin², Wei-Lun Lo³

¹Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; Department of Obstetrics and Gynecology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr Sardjito General Hospital, Yogyakarta 55281, Indonesia.

Biomedical journal

|July 26, 2024

概括

使用间歇性甲爆刺激 (iTBS) 进行重复的外周磁性刺激 (rPMS) 能够有效地减少大鼠过度活动膀症状. 这种非侵入性技术在治疗过度活动的膀 (OAB) 没有侵入性手术的情况下显示出有前途.

科学领域:

神经科学是一个神经科学.
泌尿器科泌尿器科泌尿器科泌尿器科
生物医学工程生物医学工程

背景情况:

过度活性膀 (OAB) 提出了治疗挑战,通常需要侵入性方法.
重复的外周磁性刺激 (rPMS) 提供了一个潜在的非侵入性治疗途径.

研究的目的:

评估圣神经rPMS的疗效,特别是间歇性甲突发刺激 (iTBS),用于治疗过度活性膀 (OAB).

主要方法:

在33只老鼠中,使用乙酸 (AA) 输液诱导过活的膀.
囊管测量仪 (CMG) 测量了肠道压力和膀活动.
与iTBS配合的圣体rPMS被应用来评估治疗效果.

主要成果:

在健康的老鼠中,与iTBS配合的RPMS显著增加了排泄时间和收缩间隔.
AA诱导的OAB模型显示,空气排放时间和间歇收缩间隔减少.
与iTBS一起的圣体rPMS有效地抑制了AA诱导的膀过活,显著增加了收缩间隔.

结论:

在老鼠模型中,使用iTBS的圣神经rPMS有效地抑制了乙酸诱导的膀过活.
这种非侵入性神经调节技术为管理OAB提供了潜在的替代方案.
进一步的发展可能会导致OAB患者的膀kontinence增加.

关键词:

间歇性泰达爆发刺激磁性刺激是一种磁性刺激.过度活动的膀重复的外围磁刺激是重复的外围磁刺激.节骨神经刺激神经刺激

更多相关视频

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

Published on: September 12, 2012

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

相关概念视频

Feedback Regulation of Calcium Concentration

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

Muscle Stimulation Frequency

Muscle Stimulation Frequency

The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...