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在高脂肪饮食养的老鼠中操纵养模式改善了微生物群组成动态,炎症和肠-大脑信号传递
E A Klingbeil1, R Schade2, S H Lee3
1Department of Nutritional Sciences, The University of Texas at Austin, United States.
Physiology & behavior
|July 26, 2024
概括
减少饮食频率,而不仅仅是卡路里摄入量,可以改善代谢健康. 这项研究表明,限制在高脂肪饮食中吃零食的食老鼠改善了肠道微生物群和代谢结果.
科学领域:
- 代谢健康 代谢健康
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 慢性高脂肪 (HF) 饮食增加了食的频率和大小,导致过度进食和代谢障碍.
- 饮食引起的肠道微生物群的变化对于代谢疾病的发展至关重要.
- 减少饮食频率和加入禁食可能会改善代谢健康,而不依赖于热量摄入量.
研究的目的:
- 为了研究通过对照养来减少食频率是否能改善高频养大鼠的微生物群组成和代谢结果.
- 为了确定操纵养模式是否会影响肠道微生物群和相关代谢参数.
- 评估减少零食对胃肠功能,炎症和葡萄糖耐受性的影响.
主要方法:
- 雄性Wistar大鼠被食HF,低脂肪 (LF) 或双HF (HF-PF) 饮食7周.
- HF-PF组的每日摄入量与HF组相同,但是在一次性饮食中.
- 评估了口服葡萄糖耐受性,胆固醇基因素敏感性和便微生物群组成 (16S rRNA测序).
主要成果:
- 双人养模式减少了饮食频率,特别是零食,但没有改变总热量摄入量或体重.
- 高射率-PF大鼠表现出与肥胖相关的细菌的丰度减少,并保持微生物昼夜节律.
- 在胃肠道功能,炎症,葡萄糖耐受性和肠-大脑信号传输方面观察到改善.
结论:
- 食频率的定位和减少零食可以改善代谢健康,而不管总热量消耗.
- 调节饮食模式为改善与肥胖相关的代谢障碍提供了一个潜在的策略.
- 肠道微生物群的转变和恢复的昼夜波动是将养模式与代谢改善联系起来的关键机制.
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