墨西哥的一个多中心的Candida auris疫情:2020年至2023年
Patricia Rodríguez-de la Garza1, Carlos de la Cruz-de la Cruz1, José Iván Castillo Bejarano2
1Department of Internal Medicine; Christus Muguerza Hospital Alta Especialidad, Universidad de Monterrey, Monterrey, Mexico.
American journal of infection control
|July 26, 2024
概括
墨西哥的一次多中心的Candida auris疫情影响了37名患者,其中许多人从殖民到感染. 观察到高死亡率,但 echinocandins 显示出有希望的易感性.
科学领域:
- * 传染病 传染病
- * 临床微生物学 临床微生物学
- * 流行病学 流行病学
背景情况:
- *Candida auris是一种多药性耐药酵母,导致全球健康问题和医院疫情爆发.
- *COVID-19大流行与全球Candida auris疫情的增加同时发生.
- *本研究详细介绍了墨西哥私人医疗机构的多中心疫情.
研究的目的:
- * 描述同时发生的Candida auris疫情的临床和微生物特征.
- * 在疫情爆发期间分析患者的结局和抗真菌敏感性.
主要方法:
- * 在四个医院机构进行了回顾性观察性研究.
- *包括2020年9月至2023年12月患有Candida auris殖民或感染的患者.
- *收集有关人口统计,临床表现,治疗和结果的数据.
主要成果:
- *发现了37例病例,主要是男性 (平均年龄为55.8岁).
- * 32.4%的病例从定居到感染,与更长的ICU/住院时间和机械通风有关.
- *高死亡率 (40.5%);富可纳耐药性是常见的,但类药物 (anidulafungin,caspofungin) 显示出不同的敏感性.
结论:
- *在以前被殖民的患者中发生了显著的感染率.
- *较长的住院时间与感染进展有关.
- *注意到对类素的高度敏感性,提供了潜在的治疗途径.
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