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在新生儿中检测膜部位的简单疹病毒

Rachel J Graf¹, Ingrith Viviana Hoyos García², Alvaro Dendi³

¹The Ohio State University College of Medicine, Columbus, OH; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH.

The Journal of pediatrics

|July 26, 2024

概括

简单疹病毒 (HSV) 通过聚合酶链反应 (PCR) 检测到14%的新生儿来自没有病变的粘膜部位. 这一发现的临床意义需要进一步调查.

科学领域:

新生儿传染病新生儿传染病
病毒学病毒学
分子诊断学分子诊断学

背景情况:

新生儿感染简单疹病毒 (HSV) 可能导致严重的发病率和死亡率.
早期检测和诊断对于有效管理至关重要.
无症状的粘膜脱落在新生儿HSV中的作用尚未完全理解.

研究的目的:

为了研究没有临床病变的新生儿的粘膜部位的阳性HSV聚合酶链反应 (PCR) 结果的发生率和影响.
为了确定无症状的粘膜PCR阳性是否代表早期感染,殖民或假阳性.

主要方法:

在2001年至2023年期间,对新生儿确诊的HSV感染病例进行了回顾性分析.
对诊断数据的审查,重点是粘膜部位的PCR结果.
PCR发现与临床粘膜病变的存在或不存在的相关性.

主要成果:

在120名确诊感染HSV的新生儿中,17名 (14%) 通过PCR测试,仅从粘膜部位检测出HSV阳性.
这些积极的结果是在没有任何可见的临床粘膜病变的情况下获得的.
这些特定病例的临床过程和结果在摘要中没有详细说明.

结论:

有证实HSV感染的新生儿中很大一部分可能在没有明显病变的粘膜部位获得了阳性PCR结果.
这些发现的临床意义尚不清楚,需要进一步研究.
在新生儿HSV管理中,区分早期感染,暂时殖民和假阳性是非常重要的.

关键词:

这是一个PCRPCR.乙环维尔是一种新生儿疹新生儿疹这是新生儿新生儿.

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