为COVID-19引起的ARDS的重症患者提供高压氧气的五次会议:一个随机的,开放的标签,第二阶段试验
Anders Kjellberg1, Johan Douglas2, Michael T Pawlik3
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Medical Unit Intensive Care and Thoracic Surgery, Hyperbaric Medicine, Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
高压氧气治疗 (HBOT) 并没有减少COVID-19引起的急性呼吸困扰综合征 (ARDS) 的重症监护室入院. 虽然HBOT是可行的,但没有显著的益处,并且与标准护理相似的安全性.
科学领域:
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
- 氧气疗法是一种氧气疗法.
背景情况:
- 对于COVID-19引起的ARDS,治疗选择有限.
- 在这种情况下,缺乏关于高压氧气疗法 (HBOT) 益处和危害的数据.
研究的目的:
- 评估HBOT作为适度至严重的COVID-19引起的ARDS的辅助疗法的益处和危害.
- 在第30天之前评估HBOT对ICU入院率的影响.
主要方法:
- 在瑞典和德国的三个医院进行开放式随机试验.
- 患有中度至重度ARDS和风险因素的患者被随机分配到单独接受HBOT或最佳实践.
- 主要终点:在第30天之前进入ICU. 审判因徒劳而提前结束.
主要成果:
- 34名患者随机选择 (18名HBOT,16名对照). 在ICU入院没有统计学上显著的差异 (50%控制对比72%HBOT;OR2.54 [95%CI0.62-10.39],p=0.19).
- 记录了102次不良事件,94%的HBOT和93%的控制组至少经历了一次AE.
- 三个可能与HBOT相关的严重不良事件;所有原因的死亡率不太可能与HBOT相关.
结论:
- 在COVID-19引起的ARDS患者中,HBOT没有降低ICU入院或死亡率.
- 试验无法确定最终的益处或危害.
- 对于治疗COVID-19引起的ARDS,HBOT似乎是可行的,具有有利的安全性.
更多相关视频
09:36Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
05:46A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-IV
