通过自制皮克林乳液增强界面交付的烯酸的生物可访问性:油类型的影响
Benyang Li1, Haiyan Li1, Shuxian Su1
1Department of Food Science and Technology, College of Food Science and Technology, Hunan Agricultural University, No. 1 Nongda Road, Furong District, Changsha, Hunan 410128, China.
Food research international (Ottawa, Ont.)
|July 26, 2024
概括
这项研究开发了一种使用W/O Pickering乳液的醇酸 (OA) 输送系统. 长链甘油三化物 (LCT) 通过增强微粒溶解来提高OA的生物可访问性,超过了自由脂肪酸释放效应.
科学领域:
- 食品科学与技术 食品科学与技术
- 合体和表面化学
- 营养科学 营养科学
背景情况:
- 五环三烯与烯酸 (OA) 一样具有宝贵的生物活性,但其生物可访问性较低.
- 开发有效的输送系统对于提高这些化合物的生物可用性至关重要.
研究的目的:
- 研究不同油类型 (MCT,LCT,MCT/LCT) 对W/O皮克林乳液特性的影响.
- 评估这些乳液对烯酸 (OA) 生物可访问性的影响.
- 建立使用W/O皮克林乳液的OA接口输送模型.
主要方法:
- 用中链甘油三化物 (MCT),长链甘油三化物 (LCT) 或 1:1 MCT/LCT混合物作为载体油制备W/O皮克林乳液.
- 乳液性质的表征,包括模拟体外消化过程中的颗粒大小和稳定性.
- 自由脂肪酸 (FFA) 释放量和OA生物可访问性的量化.
主要成果:
- 用LCT制备的乳液呈现出更小的颗粒大小和在消化过程中增强的稳定性.
- FFA发布顺序为MCT>M/L>LCT.
- 氧化的生物可访问性按照LCT>M/L>MCT>PBS的顺序进行,LCT显示最高值 (59.34%).
结论:
- 载体油的选择显著影响了 W/O Pickering 乳液界面输送系统中 OA 的生物可访问性.
- 通过LCT提高OA的生物可访问性主要是由于长链脂肪酸形成的混合基中溶解度增加.
- 混合菌中的疏水域的大小在确定OA生物可访问性方面比FFA释放起更为关键的作用.
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