在口腔状细胞癌的骨侵袭中TP阳性CAF的影响
Aihua Gao1, Dong Wook Kim2, Meiling Pei3
1Department of Oncology, Yanbian University Hospital, Yanji, P.R. China.
Anticancer research
|July 26, 2024
概括
硫胺酸酶阳性癌症相关纤维细胞 (TP+CAF) 在口腔状细胞癌 (OSCC) 中驱动骨入侵. 准TP+CAF可能会改善骨转移的OSCC患者的早期诊断和治疗.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 纤维细胞研究 纤维细胞研究
背景情况:
- 与癌症相关的纤维细胞 (CAF) 参与口腔状细胞癌 (OSCC) 骨侵袭.
- 在OSCC骨转移中CAF亚型的特定作用和分子机制尚不清楚.
- 胺酸酶 (TP) 阳性CAFs (TP+CAFs) 被研究为潜在的骨侵袭驱动因素.
研究的目的:
- 调查TP+CAFs在OSCC骨干侵袭中的作用.
- 确定TP+CAF与OSCC患者的临床结果之间的关联.
- 阐明TP对CAF行为和骨再吸收的功能影响.
主要方法:
- 免疫组织化学用于评估116名OSCC患者组织中的TP表达.
- 在体外实验中评估了TP对CAF生物行为的影响.
- 患者衍生异种移植 (PDX) 鼠标模型评估了TP+CAFs对OSCC骨干侵袭的影响.
主要成果:
- 在侵袭性OSCC中,TP+CAF主要位于再吸收的骨表面.
- 高TP+CAF水平与先进的T阶段,骨入侵和较差的生存率有显著的相关性.
- TP增强了CAF的扩散,入侵和矩阵金属蛋白酶-9的表达,促进了体外和体内骨的再吸收.
结论:
- TP+CAF与OSCC的骨侵袭和预后有显著的关联.
- 这些发现突出了TP+CAF作为早期诊断和骨转移性OSCC治疗点的潜在生物标志物.
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