相关实验视频

Updated: Jun 19, 2025

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

在HR+/HER2-乳腺癌中非哨兵淋巴结转移的危险因素乳腺癌与cN0

Yong Min Na¹, Sang Chun Park¹, Young Jae Ryu¹

¹Department of Surgery, Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea.

Anticancer research

|July 26, 2024

概括

对于荷尔蒙受体阳性,HER2阴性乳腺癌和阳性哨兵淋巴结,阳性哨兵淋巴结比率大于0.55是非哨兵淋巴结转移的关键预测因素.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
病理学病理学病理学

背景情况:

准确的乳腺癌分期对于治疗决策至关重要.
在激素受体 (HR) 阳性,人体表皮生长因子受体2 (HER2) 阴性,有阳性哨兵淋巴结 (SLN) 的乳腺癌中预测非哨兵淋巴结 (SLN) 转移的因素的识别至关重要.

研究的目的:

为了确定非SLN转移的风险因素,HR+,HER2-乳腺癌患者cN0和阳性SLNs.
为了确定SLN比率的最佳值,以指导骨淋巴结解剖 (ALND) 决策.

主要方法:

从2013年1月到2020年1月的医疗记录的回顾性审查.
包括HR+,HER2-乳腺癌患者,因为阳性SLNs而接受ALND.
分析临床和病理数据,包括SLN状态,瘤大小和患者人口统计数据.

主要成果:

总共有166名患者进行了分析.
单变量分析显示,非SLN转移与阳性SLN数量,SLN阳性比率和原发性瘤大小之间存在显著的关联.
多变量分析发现SLN比率>0.55作为非SLN转移的独立预测因子 (HR=3.007).

结论:

0.55或更高的SLN比率是该患者队列中非SLN转移的显著预测指标.
对于SLN比率≥0.55.5的患者,建议考虑完成ALND.
这种策略可以通过辅助疗法或减少不必要的手术来促进生存益处.

关键词:

乳腺癌是什么? 乳腺癌是什么非哨兵淋巴结的非哨兵淋巴结风险因素的风险因素是什么哨兵淋巴结活组织检查

更多相关视频

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...