乳腺癌中的新辅助与辅助系统疗法:一项匹配的病例控制研究
Mara Caroprese1, Manuel Conson1, Angela Barillaro1
1Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy.
Anticancer research
|July 26, 2024
概括
乳腺癌的新辅助全身疗法 (NAT) 显示,与辅助疗法 (AD) 的整体存活率和远程无转移存活率相似. 病理节点反应是NAT患者结果的关键预测因素,使得个性化治疗成为可能.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 临床治疗学 临床治疗学
背景情况:
- 新辅助全身疗法 (NAT) 旨在改善手术结果,并预防乳腺癌的远期复发.
- 通过根据治疗反应进行治疗调整,NAT提供了个性化治疗的潜力.
- 与辅助疗法 (AD) 相比,支持NAT改善结果的证据仍在发展.
研究的目的:
- 在乳腺癌患者中,评估NAT与AD相比的有效性.
- 评估整体存活率 (OS),局部区域无复发存活率 (LRRFS) 和远程转移无存活率 (DMFS).
- 确定影响NAT治疗患者预后结果的预后因素.
主要方法:
- 对127名接受NAT和术后放射治疗的乳腺癌患者 (2004-2021) 的回顾性分析.
- 与同一时期接受AD治疗的匹配患者队列进行比较.
- 分析的结果包括OS,LRRFS和DMFS.
主要成果:
- 五年预测的生存率:87% (NAT) 与81.5% (AD) 相比 (p=0.179).
- 五年预测的LRRFS:93.2% (NAT) 与100% (AD) 相比 (p=0.005).
- 五年预测的DMFS:84.6% (NAT) 与82.1% (AD) 相比 (p=0.367).
- 在NAT组中,病理节点反应是OS的显著预后因素 (95.6%与75.1%相比).
结论:
- 在DMFS和OS方面,NAT的疗效与AD相似.
- NAT为个性化治疗调制提供了宝贵的机会,特别是在节点阳性乳腺癌中.
- 病理节点反应是预测NAT患者结果的关键指标.
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