一个对感知至关重要的 transthalamic 途径
Christina Mo1,2, Claire McKinnon3, S Murray Sherman4
1The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia. christina.mo@florey.edu.au.
Nature communications
|July 26, 2024
概括
感官处理至关重要的 Transthalamic 路径,传递与任务相关的信息以进行感知. 抑制这些途径损害了小鼠的纹理歧视,揭示了它们在决策中的低估作用.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 感知决策 - - 感知决策
背景情况:
- 感知依赖于皮层处理和区域间通信.
- 跨体内 (皮质-体内-皮质) 路径与直接的皮质皮质路径平行,但研究不足.
- 在感官处理中 transthalamic 路径的作用仍然在很大程度上未被探索.
研究的目的:
- 为了研究 transthalamic 途径在感官处理和感知决策中的作用.
- 为了确定 transthalamic 路径是否传播与任务相关的信息来进行感官决策.
- 通过检查 transthalamic 途径的功能来挑战皮质中心的感知观点.
主要方法:
- 在小鼠的更高阶体感性丘脑中,对 transthalamic 路径的光遗传抑制.
- 小鼠执行了基于纹理的歧视任务.
- 双光子成像监测了主要和次要体感皮质中的细胞活动.
主要成果:
- 抑制跨甲状腺通路严重损害了纹理分辨性能.
- 直接的皮质皮质突出仍然完好无损,这表明 transthalamic 路线的关键作用.
- 细胞对纹理刺激的反应不受影响,但纹理选择性受到干扰,特别是在二级皮层.
- 这种选择性中断在二级皮质中更加明显,表明了前影响.
结论:
- 跨thalamic通路对于将任务相关信息传播到用于感知决策的更高阶皮质至关重要.
- 这些路径是被低估的等级路线,对感官知觉至关重要.
- 这些发现挑战了纯粹的皮质中心感知模型,突出了跨体内沟通的重要性.
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