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为患有百日咳的儿童开发和验证诊断预测模型

Qiang Gao¹, Die Xu¹, XiaoYan Guan²

¹Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 8, Section 2, Kangcheng Road, Luzhou, 646000, Sichuan, China.

Scientific reports

|July 26, 2024

概括

使用血液检测结果的新模型可以准确预测儿童的百日咳. 这种基于白细胞计数,C反应蛋白和血小板比率的诊断工具有助于对疑似百日咳的临床决定.

科学领域:

儿科儿科儿科
传染性疾病传染性疾病
诊断医学诊断医学

背景情况:

在儿童中诊断百日咳 (百日咳) 可能具有挑战性.
准确及时诊断对于有效的治疗和公共卫生管理至关重要.

研究的目的:

开发和验证使用常规血液参数对儿童咳的诊断预测模型.
在儿科患者中识别与百日咳相关的关键血液指标.

主要方法:

对477名怀疑患有百日咳的儿童进行了回顾性研究.
使用逐步回归分析开发和验证预测模型.
包括诸如白细胞计数,血红素,淋巴细胞计数,C反应蛋白和血小板分布宽度等参数,以表示血小板体积比率.

主要成果:

白细胞计数,C反应蛋白和血小板分布宽度与平均血小板体积比率被确定为独立的预测因素.
开发的模型显示了令人满意的区分能力,ROC曲线下的面积为0.77 (培训) 和0.80 (验证).
该模型在培训和验证队伍中实现了良好的灵敏度和特异性.

结论:

使用特定血液参数 (WBC,CRP,PDW-MPV-R) 的预测模型显示了在儿童咳诊断方面出色的性能.
这种模型可以在怀疑儿科 pertussis 病例的临床决策中作为一个有价值的参考.
基于血液参数的模型提供了一种可靠的方法来预测百日咳的概率.

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