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乳酸菌 (Lactobacillus rhamnosus GG) 作为早产婴儿的益生菌:一个菌株特定的系统审查和元分析

Anitha Ananthan¹, Haribalakrishna Balasubramanian², Chandra Rath³

¹Department of Neonatology, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India. ani.gem81@gmail.com.

European journal of clinical nutrition

|July 26, 2024

概括

乳酸菌拉姆诺索斯GG (LGG) 显著降低了在早产婴儿死亡性肠球炎 (NEC) 的风险,当作为唯一的益生菌. 然而,LGG对其他结果,如停留时间或死亡率没有显著影响.

科学领域:

新生儿医学新生儿医学
微生物学微生物学
基于证据的医学基于证据的医学.

背景情况:

益生菌的有效性是菌株特异性的,需要对个体菌株进行专注研究.
乳酸菌 (Lactobacillus rhamnosus GG,简称LGG) 是一种经过充分研究的益生菌,在早产婴儿中具有潜在的益处.
对LGG在这个脆弱人群中的菌株特异性影响的全面评估至关重要.

研究的目的:

在早产婴儿中系统评估Lactobacillus rhamnosus GG (LGG) 的菌株特异性影响.
综合来自随机对照试验 (RCT) 和非RCT关于LGG对关键新生儿结局的影响的证据.

主要方法:

系统审查和元分析遵循柯克兰方法和PRISMA指南.
在主要数据库 (Cochrane,PubMed,EMBASE,CINAHL) 进行搜索,截至2023年12月.
分析了来自RCT和非RCT的数据,按研究设计分层.

主要成果:

对RCT的分析显示,LGG作为唯一益生菌显著降低了死性肠球炎 (NEC) ≥II期的风险 (RR:0.50,P=0.03).
在RCT中,没有观察到晚发性败血症 (LOS),死亡率,完全养时间或住院时间的显著差异.
非RCT数据没有证明LGG对NEC,LOS或死亡率有显著影响.

结论:

当作为唯一益生菌使用时,Lactobacillus rhamnosus GG在降低早产婴儿NEC风险方面表现出有益的作用.
观察性研究没有证实RCT中发现的有益效果,这突显了研究设计的重要性.
这种特定菌株的系统审查提供了有价值的数据,以指导未来关于早产新生儿LGG的研究和临床实践.

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