利用瘤微环境来促进采用T细胞疗法,用于固体瘤的工程淋巴细胞
Martina Spiga1, Elisa Martini1, Maria Chiara Maffia1
1Experimental Hematology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Seminars in immunopathology
|July 26, 2024
概括
采用细胞疗法 (ACT) 对血液癌症有希望,但与固体瘤斗争. 新的策略利用瘤微环境 (TME) 来增强CAR-T和TCR-T细胞疗法,以获得更好的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 使用化学抗原受体 (CAR) 和T细胞受体 (TCR) 工程T细胞的采用细胞疗法 (ACT) 是治疗血液性恶性瘤的有效方法.
- 由于瘤微环境 (TME) 带来的挑战,其在固体瘤中的有效性仍然有限.
研究的目的:
- 探索克服TME诱导障碍的策略,以提高ACT在固体瘤中的有效性.
- 研究如何利用新的技术工具来提高TME内的CAR-T和TCR-T细胞性能.
主要方法:
- 审查ACT对固体瘤的当前挑战,包括TME内的物理障碍和抑制信号.
- 检查结合ACT与化疗/放射治疗和检查点抑制剂的协同方法.
- 研究用于TME调制和T细胞增强的先进技术工具.
主要成果:
- TME对ACT构成显著的物理和免疫障碍,影响T细胞功能.
- 将ACT与其他疗法结合起来可以缓解一些与TME相关的障碍.
- 新兴技术提供了利用或克服TME特征的方法,以促进T细胞的定位,生存和功能.
结论:
- 克服TME障碍对于成功的实体瘤ACT至关重要.
- 创新的方法,包括利用化学激素梯度,整合素表达,代谢重编程和合成受体,具有显著的潜力来增强CAR-T和TCR-T细胞疗法.
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