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质子疗法降低了乳腺癌患者免疫细胞的有效剂量

Pierre Loap¹, Jeremi Vu-Bezin², Ludovic De Marzi^2,3

¹Department of Radiation Oncology, Institut Curie, Paris, France. pierre.loap@gmail.com.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

|July 26, 2024

概括

强度调节质子疗法 (IMPT) 在接受放射治疗的乳腺癌患者中显著降低了循环免疫细胞 (EDIC) 的有效剂量. 这种先进的技术可以改善器官节约,从而改善患者的治疗结果.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
在瘤学瘤学.

背景情况:

循环免疫细胞的有效剂量 (EDIC) 是肺癌和食道癌患者生存的预后因素.
评估强度调制质子疗法 (IMPT) 对于EDIC减轻与体积调制弧线疗法 (VMAT) 相比,对于局部晚期乳腺癌 (BC) 治疗至关重要.

研究的目的:

在局部晚期乳腺癌患者中,与VMAT相比,评估IMPT降低EDIC的益处.
用IMPT分析影响EDIC减少的剂量计参数.

主要方法:

对10名BC患者的回顾性分析,这些患者接受了VMAT治疗,用于局部区域放射治疗.
使用包含平均器官剂量 (心脏,肺,肝脏) 和积分剂量的公式计算EDIC.
在VMAT和IMPT治疗计划之间比较EDIC.

主要成果:

IMPT显著降低了EDIC中位数,从3.37 Gy (VMAT) 降至2.13 Gy (IMPT) (p < 0.01).
在左侧 (3.15 Gy 到 1.65 Gy) 和右侧 (5.60 Gy 到 3.38 Gy) 的BC患者中观察到显著的EDIC减少 (p < 0.01).
综合剂量减少与IMPT是EDIC减少的主要驱动因素,与肺节省 (左侧BC) 或肝节省 (右侧BC) 相关.

结论:

在接受局部区域辅助放射治疗的乳腺癌患者中,IMPT表明EDIC显著减少.
降低整体总剂量,加上器官特异性节约,是IMPT降低EDIC的有效性的关键.
未来的动态模型可能比目前的静态EDIC计算提供更准确的免疫系统剂量估计.

关键词:

免疫系统的免疫系统.强度调节的质子疗法强度调节的质子疗法.后期影响后期影响地方区域辐射辐射.卷度调制弧形疗法是一种体积调制的弧形疗法.

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