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在瘤微环境中的瘤相关巨细胞再教育方面的进展

Yiming Zhao¹, Qianyang Ni¹, Weijian Zhang¹

¹Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical University, No.139, Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, China.

Discover oncology

|July 26, 2024

概括

重编程瘤相关巨细胞 (TAM) 是改善癌症免疫疗法的关键. 本综述对改变瘤微环境 (TME) 和增强抗瘤免疫力的方法进行了分类.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物医学工程生物医学工程

背景情况:

恶性瘤仍然是一个重大的全球健康威胁,传统疗法提供了不理想的预后.
免疫疗法已成为有前途的癌症治疗方法,但其全部潜力受到瘤微环境 (TME) 内的挑战的阻碍.
巨细胞,特别是瘤相关巨细胞 (TAMs),是TME内的关键的先天性免疫细胞,影响免疫反应和瘤进展.

研究的目的:

探索重编程TME以增强抗瘤免疫力的策略.
调查改变TAM招募和两极分化的方法.
为改善癌症治疗提供对TAM调节当前方法的全面概述.

主要方法:

对针对TAMs的现有治疗方法的审查和分类.
分析包括纳米粒子和光动力疗法在内的方法,以了解它们对巨细胞两极分化的影响.
在TME中组织重新编程TAM的策略.

主要成果:

确定了各种治疗方式,能够影响TME内的巨细胞两极分化.
强调TAM重编程在克服免疫治疗障碍方面的关键作用.
提供了当前TAM定位策略的结构化概述.

结论:

重编程TAM是一种有前途的策略,可以提高癌症免疫治疗的疗效.
了解和操纵TME,特别是TAM行为,对于开发新瘤疗法至关重要.
本综述提供了TAM重编程策略对未来癌症治疗的临床应用的见解.

关键词:

巨细胞的两极分化纳米颗粒纳米颗粒光动力学疗法是一种光动力学疗法.与瘤相关的巨细胞.瘤微环境中的微环境

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