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Updated: Jun 19, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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一种TNIP1驱动的全身性自身免疫性疾病,IgG4升高

Arti Medhavy1, Vicki Athanasopoulos1, Katharine Bassett1

  • 1Division of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

Nature immunology
|July 26, 2024
PubMed
概括

一种罕见的TNIP1基因变异通过破坏线粒体修复和增加托尔类受体7 (TLR7) 信号传递,导致全身性自身免疫性疾病. 这一发现表明了针对TLR7的潜在新疗法,用于自身免疫性疾病.

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Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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The immune...
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
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Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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