益生菌在治疗炎症性肠病中的作用
1Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Chicago Medicine, Chicago, IL, USA. sguandalini@bsd.uchicago.edu.
Advances in experimental medicine and biology
|July 26, 2024
概括
益生菌对性结肠炎 (UC) 治疗和维护有希望,但目前的证据不支持它们用于克罗恩病 (CD) 管理. 对于在炎症性肠道疾病 (IBD) 中进行个性化益生菌疗法,需要进一步的研究.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠道疾病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),是慢性肠道疾病,治疗选择有限,副作用很大.
- 肠道微生物群与胃肠道粘膜的相互作用在IBD病变发生过程中起着至关重要的作用.
- 益生菌正在成为IBD的潜在治疗替代品,因为它们的安全性.
研究的目的:
- 审查目前关于益生菌在治疗炎症性肠病 (IBD) 中有效性的证据.
- 为了区分益生菌在克罗恩氏病和性结肠炎中的潜在益处.
- 突出IBD益生菌研究的未来方向,包括个性化的方法.
主要方法:
- 对IBD中益生菌机制的体外和体内实验研究的综述.
- 对有关益生菌用于IBD诱导和缓解的临床试验数据的分析.
- 对UC和CD中的特定益生菌菌株和多菌株制剂的证据综合.
主要成果:
- 临床试验显示,益生菌在诱导或维持克罗恩病 (CD) 缓解方面取得了令人失望的结果.
- 证据支持特定益生菌菌株或制剂用于治疗性结肠炎 (UC) 的治疗和维持疗法的疗效.
- 在IBD中益生菌机制已被广泛研究,但临床结果因疾病和菌株而异.
结论:
- 益生菌目前不推用于克罗恩病 (CD) 管理.
- 某些益生菌在治疗和维持性结肠炎 (UC) 缓解方面表现出临床疗效.
- 益生菌组学领域为开发IBD精确和个性化的益生菌疗法提供了潜力.
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