预测风险因素和评分系统与慢性乙型肝炎中肝细胞癌的发展有关
Ploutarchos Pastras1, Evaggelos Zazas1, Maria Kalafateli1
1Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.
Cancers
|July 27, 2024
概括
高龄,男性性别,滥用酒精和肝硬化是慢性乙型肝炎患者肝细胞癌 (HCC) 的关键危险因素. GAG-HCC和PAGE-B得分在预测HCC风险方面表现良好.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 病毒性肝炎研究研究
背景情况:
- 慢性乙型肝炎 (CHB) 是肝细胞癌 (HCC) 的主要驱动因素.
- 识别HCC风险因素和预后得分对于CHB患者的早期检测和管理至关重要.
- 本研究评估了基线风险因素和CHB队列中HCC发展的预后得分.
研究的目的:
- 为了确定与CHB患者中HCC发展相关的基线风险因素.
- 在CHB患者中评估各种HCC风险评分的预后性能.
- 为了确定GAG-HCC和PAGE-B得分在预测HCC风险方面的有效性.
主要方法:
- 对632名成年CHB患者进行了观察性,回顾性研究 (01/1993-09/2020).
- 核心促进子突变的计算,GAG-HCC,CU-HCC,REACH-B,FIB-4和PAGE-B预后得分.
- 多变量考克斯回归和接收器操作曲线分析,以评估风险因素和评分绩效.
主要成果:
- 在5.38%的患者中发生HCC.
- HCC的独立预测因素是晚年,男性性别,酒精滥用和基线肝硬化.
- GAG-HCC (c-统计:0.895) 和PAGE-B (c-统计:0.857) 显示出最高的预后性能.
- 肝硬化患者的得分表现下降,治疗和未治疗组之间存在差异.
结论:
- 高龄,男性性别,滥用酒精和肝硬化是CHB中HCC的重要独立风险因素.
- 在CHB中,GAG-HCC和PAGE-B分数为HCC风险评估提供了高的歧视力.
- 需要进一步的研究来开发更具体的预后分数,用于不同的CHB亚组,特别是那些肝硬化.
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