免疫检查点抑制剂和CAR-T细胞疗法诱导的免疫相关不良事件:基于成像的综合性审查
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
Chiara Pozzessere1, Bianca Mazini1, Patrick Omoumi1
1Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland.
Cancers
|July 27, 2024
概括
免疫疗法可以改善癌症的治疗,但会导致影响任何器官的免疫相关不良事件. 使用成像和病理学的快速,多学科诊断对于有效管理这些毒性至关重要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫疗法,包括免疫检查点抑制剂和仿真抗原受体T细胞,已经改变了癌症治疗.
- 这些疗法增强免疫反应,但可能导致影响任何器官系统的免疫相关不良事件 (irAEs).
- 不良反应的范围从轻微 (皮肤炎) 到严重 (心肌炎),在治疗期间可以随时发生.
研究的目的:
- 为各种与现代免疫疗法相关的系统特异性毒性提供基于成像的审查.
- 突出一种多学科的方法来诊断和管理irAEs.
- 提供放射性见解,以区分irAEs与模仿者,如瘤进展或感染.
主要方法:
- 对irAEs的临床特征,成像特征和病理模式的审查.
- 强调诊断挑战和差异诊断.
- 整合基于毒性严重程度的管理策略.
主要成果:
- irAEs在各个器官系统中表现出不同的临床和成像表现.
- 从瘤进展,感染或炎症中区分irAEs需要仔细评估.
- 多学科合作和成像是准确诊断的关键.
结论:
- 及时识别和管理irAEs对于患者安全和治疗连续性至关重要.
- 成像在诊断irAEs和指导差异诊断方面发挥着关键作用.
- 对irAEs的全面理解有助于瘤学家和放射学家优化患者护理.
关键词:
用CAR T细胞疗法进行治疗.计算机断层扫描 (CT) 是一种计算机断层扫描.影像成像技术 影像成像技术免疫检查点抑制剂 免疫检查点抑制剂与免疫相关的不良事件免疫疗法 免疫疗法磁共振成像技术的使用医学瘤学 医学瘤学定子发射断层扫描/计算机断层扫描毒性的毒性 毒性的毒性更多相关视频
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