针对恶性瘤的基于贝瓦西祖马布的治疗方法 - - 关于有效性,安全性和成本的现实世界数据
Elena Chitoran1,2, Vlad Rotaru1,2, Sinziana-Octavia Ionescu1,2
1Medicine School, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Cancers
|July 27, 2024
概括
贝瓦西祖马布在现实癌症治疗中提供临床益处,类似于临床试验. 然而,这种疗法显著增加了治疗成本,需要对潜在的不良影响进行监测.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 贝瓦西祖马布广泛用于全身瘤治疗,全球有超过350万患者接受治疗.
- 它的广泛使用需要将现实世界的有效性,安全性和成本与受控临床试验数据进行比较.
- 了解贝瓦西祖马布在常规临床实践中的性能对于优化癌症护理至关重要.
研究的目的:
- 评估贝瓦西祖马布在大量癌症患者中的实际有效性,安全性和成本.
- 将不受控制的临床环境的结果与受控临床试验的数据进行比较.
- 评估贝瓦齐祖马布对无进展生存期 (PFS),整体生存期 (OS) 和反应率的影响.
主要方法:
- 在布加勒斯特瘤研究所进行了一项公开的,观察性,回顾性研究.
- 从625名患有固体恶性瘤的患者收集了数据,这些患者在2017年至2021年期间接受了基于贝瓦齐祖马布的治疗.
- 该研究分析了657次治疗事件,包括一线和随后的治疗线.
主要成果:
- 贝瓦西祖马布的整体响应率约为60-65%,在结直肠和卵巢癌的晚期治疗线下,响应率较低 (27.1%和31.5%).
- 无进展生存时间 (PFS) 中位数为8.2个月,总生存时间 (OS) 中位数为13.2个月.
- 常见的毒性包括出血,高血压和伤口愈合并发症;贝瓦西祖马布治疗成本增加了213%.
结论:
- 尽管费用昂贵,但贝瓦西祖马布在与标准化疗相结合时,提供了显著的临床益处,包括改善了OS,PFS和响应率.
- 在未经选择的患者队列中,现实世界的结果与受控临床试验的结果相匹配.
- 由于潜在的不良影响,建议监测非标签使用贝瓦西祖马布的情况.
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